Safety and immunogenicity of a replication-deficient H5N1 influenza virus vaccine lacking NS1.

Christina Nicolodi,Franz Groiss,Oleg Kiselev,Markus Wolschek,Joachim Seipelt,Thomas Muster

Vaccine（2019）

引用 13|浏览21

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摘要

•First in humans study with a live attenuated pandemic delNS1-H5N1 vaccine.•Significant serum antibody titers as measured by HAI and MNA after two immunizations.•DelNS1-H5N1 well tolerated and safe in healthy male and female participants.•No vaccine virus re-isolated in participants after one immunization.

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关键词

Influenza,NS1,Intranasal,H5N1,Live attenuated,Replication-deficient,Reverse genetics

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