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Gut resistome after oral antibiotics in preschool children in Burkina Faso: A randomized controlled trial.

Catherine E Oldenburg,Armin Hinterwirth,Ali Sié,Boubacar Coulibaly,Lucienne Ouermi,Clarisse Dah,Charlemagne Tapsoba,Susie L Cummings,Lina Zhong,Cindi Chen, Samarpita Sarkar,Till Bärnighausen,Thomas M Lietman,Jeremy D Keenan,Thuy Doan

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE（2020）

Cited 23|Views18
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Abstract
We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6-59 months in a randomized controlled trial. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.
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Key words
resistome,antimicrobial resistance,randomized controlled trial
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