Gut resistome after oral antibiotics in preschool children in Burkina Faso: A randomized controlled trial.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE(2020)
Abstract
We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6-59 months in a randomized controlled trial. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.
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Key words
resistome,antimicrobial resistance,randomized controlled trial
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