Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans.

•Type I and type II PRMTs in A. nidulans co-regulate the same biological processes.•Aspergillus PRMTs act as negative regulators of secretory genes.•The methylome is defined by overlapping as well as specific activities of RmtA and RmtC.•PRMT deletions affect expression of genes involved in oxidative stress response.