Concomitant EGFR Mutation and EML4-ALK Rearrangement in Lung Adenocarcinoma Is More Frequent in Multifocal Lesions.

Jun Fan,Xiaofang Dai, Zhenkao Wang,Bo Huang,Heshui Shi,Danju Luo,Jiwei Zhang,Weijing Cai,Xiu Nie,Fred R Hirsch

Clinical Lung Cancer（2019）

引用 25|浏览11

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摘要

The results highlight the importance of distinguishing synchronous primary tumors from intrapulmonary metastases, and of assessing the relative abundance of EGFR mutation and ALK rearrangement in patients with multifocal adenocarcinomas with EGFR/ALK co-alterations.

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关键词

Anaplastic lymphoma kinase rearrangement,Clonal evolution,Epidermal growth factor receptor,Intertumoral heterogeneity,Multifocal lung adenocarcinomas

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