Antitrypanosomal activity and effect in plasma membrane permeability of (-)-bornyl p-coumarate isolated from Piper cernuum (Piperaceae).

•Compounds 1–6 were isolated from Piper cernuum (Piperaceae).•Compounds 2, 3, 5, and 6 displayed activity against T. cruzi.•Compound 6 was the most active against T. cruzi with an IC50 = 2.1 μM and SI = 18.•The lethal action of compound 6 is directly related to structural disruption of the membrane.