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Ca 2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF.

Sambad Sharma,Shih-Ying Wu,Hugo Jimenez,Fei Xing,Dongqin Zhu,Yin Liu,Kerui Wu,Abhishek Tyagi,Dan Zhao,Hui-Wen Lo,Linda Metheny-Barlow,Peiqing Sun,John D Bourland,Michael D Chan,Alexandra Thomas,Alexandre Barbault,Ralph B D'Agostino,Christopher T Whitlow,Volker Kirchner,Carl Blackman,Boris Pasche,Kounosuke Watabe

EBioMedicine（2019）

Cited 40|Views82
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Abstract
We demonstrate that BCF, as a single agent or in combination with radiation, is a novel treatment approach to the treatment of brain metastases. This paradigm shifting modality warrants further clinical trials for this unmet medical need.
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Key words
Breast Cancer,Brain metastasis,Electromagnetic field,Radiofrequency,Calcium,Novel therapeutics,Cav3.2 T-type channel,Exosomes,Radiation,miRNA,Angiogenesis
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