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Antidepressant effects of C-Terminal domain of the heavy chain of tetanus toxin in a rat model of depression

Bruk Getachew,Liliana Mendieta,Antonei B. Csoka,José Aguilera,Yousef Tizabi

Behavioural Brain Research（2019）

Cited 8|Views22
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Abstract
•Hc-TeTx caused dose-dependent antidepressant effect in WKY rat model of depression.•Hc-TeTx caused an increase in hippocampal and frontal cortical levels of BDNF.•Hc-TeTx caused a decrease in hippocampal and frontal cortical levels of TNF-Alpha.•The results suggest potential usefulness of Hc-TeTx in PD-Depression co-morbidity.
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Key words
Helplessness,Forced swim test,BDNF,TNF-alpha,Hippocampus,Frontal cortex,Parkinson’s disease
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