Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse.
Neuroscience Research(2020)
摘要
•CPP prevent cognitive dysfunction in APP/PS2 mouse model of Alzheimer’s disease.•CPP reduce hippocampal Aβ deposition.•5-CQA, the main CPP component, degrades Aβ fibrils.•CPP have a therapeutic potential for treating cognitive deficits in AD.
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关键词
Alzheimer’s disease,Amyloid β peptides,Chlorogenic acid,Cognitive function,Polyphenolic
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