Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse.

Keiko Ishida,Masaki Yamamoto,Kensuke Misawa,Hitomi Nishimura,Koichi Misawa,Noriyasu Ota,Akira Shimotoyodome

Neuroscience Research（2020）

引用 41|浏览17

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摘要

•CPP prevent cognitive dysfunction in APP/PS2 mouse model of Alzheimer’s disease.•CPP reduce hippocampal Aβ deposition.•5-CQA, the main CPP component, degrades Aβ fibrils.•CPP have a therapeutic potential for treating cognitive deficits in AD.

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关键词

Alzheimer’s disease,Amyloid β peptides,Chlorogenic acid,Cognitive function,Polyphenolic

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