Modulation of in vitro antimalarial responses by polymorphisms in Plasmodium falciparum ABC transporters (pfmdr1 and pfmdr5)

Mathieu Gendrot,Mamadou Wague Gueye, Francis Tsombeng Foguim,Marylin Madamet, Khalifa Ababacar Wade, Mame Bou Kounta,Mansour Fall,Silman Diawara,Nicolas Benoit,Gora Lo,Raymond Bercion,Rémy Amalvict,Joel Mosnier,Bécaye Fall,Sébastien Briolant,Bakary Diatta,Bruno Pradines

Acta Tropica（2019）

引用 5|浏览23

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摘要

•Two ATP-binding cassette transporter genes (pfmdr1 and pfmdr5) sequenced in 67 P. falciparum isolates from Dakar, Senegal.•Fourteen different allelic group identified in the 67 isolates for pfmdr5.•Parasites with 8 and more than 8 repeats of DNNN motif in pfmdr5 were significantly more susceptible to piperaquine.•The wild-type allele N86 and the N86-184Y haplotype in pfmdr1 were associated with reduced susceptibility to lumefantrine.

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关键词

Malaria,Plasmodium falciparum,Antimalarial drug,In vitro,Resistance,Molecular marker,ABC transporter,pfmdr5,pfmdr1

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