Declining Skeletal Muscle Mitochondrial Function Associated With Increased Risk of Depression in Later Life.

•What is the primary question addressed in this study?○Recent studies have implicated non-normative age-related processes in the pathogenesis of late life depression. The primary question tested in this study is whether dysfunction in one such age-related process, skeletal muscle mitochondrial function, is associated with and increases risk for late life depression.•What is the main finding of this study?○The main finding of the study is that declining skeletal muscle mitochondrial function in older adults is associated with clinically significant depressive symptoms at follow-up.•What is the meaning of the finding?○This study provides preliminary support for the hypothesis that mitochondrial dysfunction may be a potential key pathophysiological mechanism in adults with late life depression.