Probing phospholipid microbubbles by atomic force microscopy to quantify bubble mechanics and nanostructural shell properties

Adeel S. Shafi,Jake McClements,Ibrahim Albaijan,Radwa H. Abou-Saleh,Carmel Moran,Vasileios Koutsos

Colloids and Surfaces B: Biointerfaces（2019）

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摘要

•Using tapping mode imaging, the thickness of microbubble shells can be quantified.•Quantifying shell thickness has significant impact on Young’s Modulus values.•Atomic force microscopy can be used to quantify thickness of the PEG brush layer.

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关键词

Atomic force microscopy,Force spectroscopy,Microbubbles,Lipid configuration,Mechanical properties,Nanostructure,Ultrasonic contrast agents,Shell thickness,Shell properties

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