Effectiveness and Mechanism of Action of Vanadyl Sulfate in Increasing Pancreatic β Cell Proliferation of DM Mice Due to Streptozotocin Induction

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia as a result of damage to insulin secretion, insulin action, or both. Vanadyl sulfate is one of the form of vanadium which has begun to be used to treat diabetes in humans. In this study, investigation on the effectiveness of vanadyl sulfate in increasing pancreatic β cell proliferation of diabetes mice due to streptozotocin induction. There were 30 healthy mice were subjected to this experimental study. Findings from this experiment proved that administration of vanadyl sulfate at various doses can significantly increase the amount of pancreatic β cell proliferation and eventually reduced blood glucose levels in a meaningless manner. However, those mice that administrated of vanadyl sulfate at a dose of 30 mg/kgBW had a higher amount of Langerhans Islet than those in the vanadyl sulfate group at a dose of 5 mg/kgBW and 100 mg/kgBW. Similar observations were obtained for the Ki-67 expression. The highest Ki-67 expression was obtained at a dose of 30 mg/kgBW but it decreased with a dose of 100 mg/kgBW of vanadyl sulfate.