Abstract 18614: Pre-Diabetes, Diabetes and Predictors of Incident Angina During Long-term Evaluation in Older Women and Men in the Cardiovascular Health Study

Introduction: Diabetes mellitus (DM) is an important risk factor for coronary heart disease (CHD) and has been considered to be a relatively stronger predictor for CHD in women than men. Angina pectoris (AP) can be a debilitating consequence of CHD. The temporal relationship between pre-diabetes (pre-DM), DM and AP among older adults without CHD at baseline has not been previously characterized. We investigated the relation of these factors, and other predictors of incident AP, among older adults. Methods: We examined in adults aged ≥65 years from the Cardiovascular Health Study, a prospective study of cardiovascular disease, incident AP event rates by sex and diabetes status. Cox regression, with calculated hazard ratios (HR), determined the risk of incident AP according to presence of pre-DM or DM, compared to neither condition, along with other risk factors, as predictors of incident AP over 15 years of follow up. Results: Among 3052 adults (mean age 71.0 ± 5.1 years, 62.2% female) without CHD at basel...