Chemical structure and snake antivenom properties of sulfated agarans obtained from Laurencia dendroidea (Ceramiales, Rhodophyta)

Luciana G. Ferreira,Ana Cláudia R. da Silva,Miguel D. Noseda,André L. Fuly,Mariana M. de Carvalho,Mutue T. Fujii,Eladio F. Sanchez,Jaqueline Carneiro,Maria Eugênia R. Duarte

Carbohydrate Polymers（2019）

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摘要

•A family of sulfated and methylated agarans was obtained from Laurencia dendroidea.•Fine chemical structure of a purified agaran fraction was determined.•Most β-d-galactose units are 2-sulfated, non sulfated or 6-O-methylated.•L-Galactose units are 6-sulfate, 3,6-anhydro, or 6-sulfate 3-xylose.•KCl-soluble agaran inhibited toxic effects of the snake venoms (L. muta, B. jararaca).

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关键词

Sulfated agaran,Chemical structure,Red seaweed,Antivenom activity,Bothrops jararaca,Lachesis muta

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