Cover Feature: Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides (ChemBioChem 1/2019)

The cover feature picture shows that deinhibition of protein phosphatase-1 (PP1) with PP1-disrupting peptide (PDP) triggers direct dephosphorylation of the kinase phosphoMEK followed by indirect dephosphorylation of the kinase phosphoERK. This finding was enabled by the complementary application of PDP-Nal, optimized in this work for enhanced stability and potency, together with protein tyrosine phosphatase inhibition. More information can be found in the communication by M. Köhn et al. on page 66 in Issue 1, 2019 (DOI: 10.1002/cbic.201800541).