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The influence of neuroinflammation in Autism Spectrum Disorder

Samantha M. Matta,Elisa L. Hill-Yardin,Peter J. Crack

Brain, Behavior, and Immunity（2019）

Cited 190|Views11
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Abstract
•Unregulated inflammation in autistic patients in the absence of insult or injury.•Microglia and astrocytes play physiological roles in synapse maintenance.•Altered glial function could contribute to neural deficits.•Emerging evidence for a role for the Gut-Brain Axis in ASD.•Glial-driven disruptions in neural connectivity may contribute to core behavioural traits in autism.
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Key words
Microglia,Neuroinflammation,Autism,ASD,Astrocytes,Cytokines,Synaptic plasticity,Neuronal communication,Neural connectivity,Gut-brain axis
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