LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer

Xianbin Zhang,Simone Kumstel,Ke Jiang,Songshu Meng,Peng Gong,Brigitte Vollmar,Dietmar Zechner

Journal of Advanced Research（2019）

引用 32|浏览13

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摘要

•LW6 inhibits proliferation and induces cell death in pancreatic cancer cells.•LW6 improves the anti-proliferation efficacy of gemcitabine.•LW6 enhances gemcitabine-induced cell death.•LW6 in combination with gemcitabine decreases tumor weight.•LW6 inhibits autophagic flux.

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关键词

LW6,Gemcitabine,Pancreatic cancer,Autophagy,Combination therapy

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