MP24-07 INFLUENCE OF REGULAR ASPIRIN INTAKE ON PSA VALUES, PROSTATE CANCER INCIDENCE AND OVERALL SURVIVAL IN A PROSPECTIVE SCREENING TRIAL COHORT (ERSPC AARAU)

You have accessJournal of UrologyProstate Cancer: Detection & Screening III (MP24)1 Apr 2019MP24-07 INFLUENCE OF REGULAR ASPIRIN INTAKE ON PSA VALUES, PROSTATE CANCER INCIDENCE AND OVERALL SURVIVAL IN A PROSPECTIVE SCREENING TRIAL COHORT (ERSPC AARAU) Lukas Gstrein*, Christopher Millan, Ashkan Mortezavi, Stephen Wyler, Lukas Manka, Andreas Huber, Rainer Grobholz, Franz Recker, Tullio Sulser, Daniel Eberli, and Maciej Kwiatkowski Lukas Gstrein*Lukas Gstrein* More articles by this author , Christopher MillanChristopher Millan More articles by this author , Ashkan MortezaviAshkan Mortezavi More articles by this author , Stephen WylerStephen Wyler More articles by this author , Lukas MankaLukas Manka More articles by this author , Andreas HuberAndreas Huber More articles by this author , Rainer GrobholzRainer Grobholz More articles by this author , Franz ReckerFranz Recker More articles by this author , Tullio SulserTullio Sulser More articles by this author , Daniel EberliDaniel Eberli More articles by this author , and Maciej KwiatkowskiMaciej Kwiatkowski More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000555632.45206.48AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Chemoprevention of prostate cancer (PCa) has been extensively investigated in the last decades. So far only 5-alpha-reductase-inhibitors (5-ARI) are supported by clinical evidence to have chemopreventive effect on PCa incidence, hence unclear in terms of prevention of aggressive PCa. Evidence for an effect of ASA on PCa is conflicting. The exact interaction pathways between ASA and carcinogenesis are still to be established. The aim of the study was to analyze the influence of ASA intake on PSA values and PCa development. METHODS: A population-based analysis including 4314 men from the European Randomized Study of Screening for Prostate Cancer (ERSPC) database was conducted. Data about drug intake, age, family history and symptoms was obtained by a self-administered questionnaire. A transrectal ultrasound guided prostate biopsy was performed in men with a PSA-level > 3 ng/ml. Tumor stage and grade were registered; incidence and mortality data were obtained through registry linkages. PCa incidence and grade, total PSA value, free-to-total PSA and overall survival were compared between ASA users and non-users, respectively. RESULTS: Median follow-up time was 9.6 years. In all, n = 789 (18.3%) men used aspirin [ASA+]. Although overall PCa incidence was significantly lower among aspirin users ([ASA+] 54 (6.8%) vs. [ASA-] 338 (9.6%), p 0.015), the multivariate cox-regression analysis did not show the decreased risk to be diagnosed with PCa ([ASA+] hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.62 - 1.16; p = 0.297) to be statistically significant. Total PSA values were significantly lower in aspirin users for both baseline (1.6 vs. 1.8 ng/ml, p = 0.007) and follow-up-visits after four years (1.75 vs. 2.1 ng/ml, p < 0.001). Multivariate cox-regression analysis predicted significantly higher overall mortality among ASA users compared to non-users ([ASA+] HR 1.46, 95% CI 1.10 to 1.94). CONCLUSIONS: In our study population we could demonstrate that ASA intake did not alter overall PCa risk in a statistically significant manner. However, the finding of persistently lower PSA values in ASA users is of potential clinical importance. It suggests that PSA cutoff values should be lowered in ASA users otherwise it may introduce potential bias towards delayed PCa detection in this group, especially outside a screening setting. On the other hand, lower PSA values may suggest a protective effect of ASA on PCa development Source of Funding: None Zurich, Switzerland; Aarau, Switzerland; Braunschweig, Germany; Aarau, Switzerland; Zurich, Switzerland; Aarau, Switzerland© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e336-e337 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lukas Gstrein* More articles by this author Christopher Millan More articles by this author Ashkan Mortezavi More articles by this author Stephen Wyler More articles by this author Lukas Manka More articles by this author Andreas Huber More articles by this author Rainer Grobholz More articles by this author Franz Recker More articles by this author Tullio Sulser More articles by this author Daniel Eberli More articles by this author Maciej Kwiatkowski More articles by this author Expand All Advertisement PDF downloadLoading ...