A Dramatic Response to Denosumab: Protracted Hypocalcemia Related to Human T-Cell Lymphotropic virus type 1-Associated Adult T-Cell Leukemia/Lymphoma

Emily Anne Japp,Michal Kasher Meron,Joel Zonszein

AACE Clinical Case Reports（2019）

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摘要

Objective: Adult T-cell leukemia/lymphoma (ATL) is known for its aggressive behavior, frequently presenting with hypercalcemia. ATL tumor cells uniquely secrete parathyroid hormone-related protein, viral peptides, and inflammatory cytokines, inducing a state of high bone turnover and activation of the receptor activator of nuclear factor kappa-B signaling pathway resulting in hypercalcemia.

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