MP05-13 HEPATITIS B SEROLOGY IS A NOVEL RISK FACTOR FOR BLADDER CANCER

INTRODUCTION AND OBJECTIVES:Chronic Hepatitis B (HepB) or Hepatitis C (HepC) infection has been well-established as an important risk factor for the development of hepatocellular carcinoma (HCC). Because HepB/C infection has been directly linked to oncogenesis, in part due to the regulation of p53 activity, it was hypothesized that there may be an association between HepB/C infection and the development of other cancer types, specifically bladder cancer.METHODS:A nationally representative cross-sectional analysis was performed using demographic and clinical data from the National Health and Nutrition Examination Survey (NHANES) database. Data from patients with any bladder cancer diagnosis over a four-year period were obtained, and positivity for Hepatitis B Surface Antibody (HBAbS), Hepatitis B Core Antibody (HBAbC), and Hepatitis C Antibody (HCAb) were analyzed as risk factors using logistic regression analyses controlling for age, smoking status, race, and BMI.RESULTS:From the NHANES database, 447,694 ...