MP40-04 PREVALENCE OF TESTOSTERONE DEFICIENCY IN MEN AGED OVER 80 YEARS IS NOT INCREASED IN NONOBESE INDIVIDUALS

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation I (MP40)1 Apr 2019MP40-04 PREVALENCE OF TESTOSTERONE DEFICIENCY IN MEN AGED OVER 80 YEARS IS NOT INCREASED IN NONOBESE INDIVIDUALS Taciana Tiraboschi, Monique Caires, Eduardo P Miranda*, Caroline Silva, Mateus Alvaia, Ueslei Menezes, Leopoldo Neto, Jose Murillo Bastos Netto, Cristiano M Gomes, and Jose Bessa Taciana TiraboschiTaciana Tiraboschi More articles by this author , Monique CairesMonique Caires More articles by this author , Eduardo P Miranda*Eduardo P Miranda* More articles by this author , Caroline SilvaCaroline Silva More articles by this author , Mateus AlvaiaMateus Alvaia More articles by this author , Ueslei MenezesUeslei Menezes More articles by this author , Leopoldo NetoLeopoldo Neto More articles by this author , Jose Murillo Bastos NettoJose Murillo Bastos Netto More articles by this author , Cristiano M GomesCristiano M Gomes More articles by this author , and Jose BessaJose Bessa More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556096.66857.a7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Epidemiological studies have demonstrated that testosterone production has a steady decline over the years. However, there have been conflicting reports assessing different patient populations in which age has not been an independent predictor of testosterone deficiency (TD). The aim of this study was to compare the prevalence of TD in a cohort of men over 80 years of age in comparison to middle-aged men and identify predictors for such condition. METHODS: Two different cohorts of patients seen at our institution from 2012 to 2018 were compared: i) patients aged >80 years seen at the geriatric center of our institution for routine follow-up (group 80+); ii) men aged 40 to 75 years who were evaluated at a prostate cancer-screening program (group 40-75). TD was defined as T levels <300ng/dl. Clinical and demographic data were obtained from medical records. Groups were compared regarding the presence of TD and metabolic syndrome (MS) components. MetS were considered present when 3 or more of the following were identified: the presence of hypertension, increased waist circumference (WC >102 cm), elevated blood glucose level (>100 ng/dl) and abnormal serum lipid profile (HDL < 40 mg/dL and triglycerides > 150 mg/dL). RESULTS: 197 subjects were included in group 80+ with a mean age (±SD) of 83±4 years (range 80-97 years), and group 40-75 had 2562 men with mean age of 56±9 years (range 40-74 years). The prevalence of TD was similar between groups: mean T (±SEM) was: 458±15 ng/dL in group 80+ and 410±8 ng/dL in group 40-75, p=0.12. The prevalence of MetS (group 80+ 28% vs. group 40-75 32%) and the number MetS components were also similar between groups (p>0.05), except for the fact that group 80+ had a higher prevalence of hypertension (73% vs. 43%, p=<0.0001) and group 40-75 had more individuals with obesity (34% vs. 21%, p=0.0001). Elevated waist circumference was the most important predictor for TD in elderly individuals, as those in the highest quartile for WC (>102 cm) were ten times more likely to have TD than those in the lowest quartile (WC<90 cm, OR=10.2, 95%CI 2.8-34.3, p<0.0001). CONCLUSIONS:: In our study, no significant difference was noted between T levels in octogenarians and middle-aged men. For individuals with WC<102 cm, age appears not to have a significant impact on T levels. Source of Funding: None Feira de Santana, Brazil© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e587-e587 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Taciana Tiraboschi More articles by this author Monique Caires More articles by this author Eduardo P Miranda* More articles by this author Caroline Silva More articles by this author Mateus Alvaia More articles by this author Ueslei Menezes More articles by this author Leopoldo Neto More articles by this author Jose Murillo Bastos Netto More articles by this author Cristiano M Gomes More articles by this author Jose Bessa More articles by this author Expand All Advertisement PDF downloadLoading ...