PROSTATE HEALTH INDEX FOR PROSTATE CANCER DETECTION IN PATIENT UNDERWENT MAGNETIC RESONANCE IMAGING TRANSRECTAL ULTRASOUND FUSION PROSTATE BIOPSY

The Journal of Urology(2019)

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You have accessJournal of UrologyProstate Cancer: Detection & Screening VI (PD35)1 Apr 2019PD35-10 PROSTATE HEALTH INDEX FOR PROSTATE CANCER DETECTION IN PATIENT UNDERWENT MAGNETIC RESONANCE IMAGING TRANSRECTAL ULTRASOUND FUSION PROSTATE BIOPSY Po-Hsun Pan*, Tzu-Ping Lin, Yu-Hua Fan, Tzu-Chun Wei, Yi-Shen Huang, Chi-Cheh Lin, Eric Y.H. Huang, Hsiao-Jen Chung, Junne-Yih Kuo, Howard H.H. Wu, Shing-Hwa Lu, Yen-Hwa Chang, Alex T.L. Lin, and William J.S. Huang Po-Hsun Pan*Po-Hsun Pan* More articles by this author , Tzu-Ping LinTzu-Ping Lin More articles by this author , Yu-Hua FanYu-Hua Fan More articles by this author , Tzu-Chun WeiTzu-Chun Wei More articles by this author , Yi-Shen HuangYi-Shen Huang More articles by this author , Chi-Cheh LinChi-Cheh Lin More articles by this author , Eric Y.H. HuangEric Y.H. Huang More articles by this author , Hsiao-Jen ChungHsiao-Jen Chung More articles by this author , Junne-Yih KuoJunne-Yih Kuo More articles by this author , Howard H.H. WuHoward H.H. Wu More articles by this author , Shing-Hwa LuShing-Hwa Lu More articles by this author , Yen-Hwa ChangYen-Hwa Chang More articles by this author , Alex T.L. LinAlex T.L. Lin More articles by this author , and William J.S. HuangWilliam J.S. Huang More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556342.55323.6fAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Prostate health index (PHI) was found to have higher accuracy rate to distinguish malignancy from benign disease compared with prostate specific antigen (PSA). MRI- transrectal ultrasound (TRUS) fusion prostate biopsy also gave a better result for prostate cancer diagnosis, but the correlation is not thoroughly elucidated. We aimed to study the predictive power of PHI on the result of MRI-TRUS fusion prostate biopsy. METHODS: We initiated this prospective study from March 2017 to August 2018. Patients with PSA > 4.0 ng/ml or abnormal finding in digital rectal examination were enrolled. Those patients underwent MRI- TRUS fusion biopsy after blood samples for serum total PSA (tPSA), free PSA (fPSA) and p2PSA. Prostate health index (PHI) was calculated. Receiver operating characteristic (ROC) curve and multivariate analysis were done for all markers between cancer and non-cancer patients. RESULTS: Total 124 patients were enrolled in this study. The median age of all patients was 68.0 years old. MRI-TURS fusion prostate biopsy identified prostate cancer in 66 patients (53.2%). Medians of all variables were compared between two groups. Age (p=0.001), PSA density (p=0.016), P2PSA percentage (<= 0.001), and PHI (p< 0.001) were higher in patients who were diagnosed to have cancer; free PSA percentage (p= 0.011) was higher in non-cancer patients. Patients who have prostate cancer have significantly smaller prostate size, (p=0.004). ROC curve revealed the area under curve of prostate volume, PSA density, tPSA, fPSA%, p2PSA% and PHI are 0.648, 0.715, 0.564, 0.653, 0.739 and 0.838. PHI gave a best result in distinguishing cancer from non-cancer patients compared with others (Figure 1). Besides, PHI has the highest odds ratio (Table 1). CONCLUSIONS: PHI not only has the best accuracy for prostate cancer detection in patient underwent systemic prostate biopsy, but also has better predictive power in MRI-TRUS fusion prostate biopsy patients. Source of Funding: none Taipei, Taiwan© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e653-e654 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Po-Hsun Pan* More articles by this author Tzu-Ping Lin More articles by this author Yu-Hua Fan More articles by this author Tzu-Chun Wei More articles by this author Yi-Shen Huang More articles by this author Chi-Cheh Lin More articles by this author Eric Y.H. Huang More articles by this author Hsiao-Jen Chung More articles by this author Junne-Yih Kuo More articles by this author Howard H.H. Wu More articles by this author Shing-Hwa Lu More articles by this author Yen-Hwa Chang More articles by this author Alex T.L. Lin More articles by this author William J.S. Huang More articles by this author Expand All Advertisement PDF downloadLoading ...
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prostate cancer detection,prostate health index,prostate cancer,ultrasound
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