Advantages and shortcomings of cell-based electrical impedance measurements as a GPCR drug discovery tool

Jordi Doijen,Tom Van Loy,Bart Landuyt,Walter Luyten,Dominique Schols,Liliane Schoofs

Biosensors and Bioelectronics（2019）

引用 20|浏览53

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摘要

G Protein-Coupled Receptors (GPCRs) transduce extracellular signals and activate intracellular pathways, usually through activating associated G proteins. Due to their involvement in many human diseases, they are recognized worldwide as valuable drug targets.

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关键词

G protein-coupled receptor (GPCR),Label-free,Cell-based,Electrical impedance,Biosensor,Drug discovery

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