Cover Feature: Synthesis of Bioactive Side‐Chain Analogues of TAN‐2483B (Chem. Asian J. 8/2019)

Side-chain analogues of the natural product TAN-2483B have been synthesised and tested for cancer cell and kinase inhibition. The furo[3,4-b]pyran scaffold was constructed through ring expansion of a mannose-derived cyclopropane, alkynylation and carbonylative lactonisation. Various side chains were appended using Wittig methodology. The cover picture illustrates key intermediates in the synthesis leading to the prepared analogues. These are overlaid on a New Zealand native fern, signifying the origin of the research presented in this special issue on Chemistry in New Zealand. More information can be found in the Full Paper by Joanne Harvey et al. on page 1230 in Issue 8, 2019 (DOI: 10.1002/asia.201801767).