Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity

Ana Cláudia Santos,Irina Pereira,Miguel Pereira-Silva,Laura Ferreira,Mariana Caldas,Mar Collado-González,Mariana Magalhães,Ana Figueiras,António J. Ribeiro,Francisco Veiga

Colloids and Surfaces B: Biointerfaces（2019）

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摘要

•Resveratrol (RES) is a polyphenolic phytoalexin.•RES physicochemical properties hinder its in vivo bioavailability.•Nanotechnology-based carriers improve RES pharmacokinetics and pharmacodynamics.•RES bioactivities may be improved through the use of nanocarriers.•RES-nanocarriers constitute a potential anticancer therapeutic strategy.

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关键词

18F FDG,Avi,AD,ALT,AST,AUC,AUC0→24h,AUC0→8h,AUC0→∞,AUC0→a,Aβ,Aβ1-42,Bio,BBB,BCS,BSA,CAM,CD,Cl,Cmax,CMCS,CoQ10,COX-2,cPLA2,CS,CS/PCL,DGG,DMBA,EE,F188,FA,GI,GSK-3β,HO-1,HPMC,HP-β-CD,HSA,i.p.i,i.v.i,ICD,IL-12,IL-1β,IL-6,iNOS,JNK,Ka,LCT,LDL,LNC,LPS,MMP,MUC- 2,MUC-3,mPEG-PCL,MRT,NPs,PAM-Chol,PBS,PCL,pDNA,PEG,PEG-PLA,PET/CT,PI,PLGA,PVA,PVP K17,RES,RGD,RM-β-CD,ROS,SL,SLN,SNEDS,SPIP,t1/2,Tem,Tf,TFF3,tmax,TNBS,TNF-α,TPGS,TTAB,ZP,α-TOH

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