Role of Acyl-CoA Short Chain Synthetase 2 and Acetyl-CoA in Regulation of Chromatin Modifications and Gene Expression

Post-translational modifications of proteins control many complex biological processes, including genome expression, chromatin dynamics, metabolism, and cell division. Histone protein acetylation and methylation have been extensively linked to the regulation of chromatin remodeling and gene expression. Chromatin modifying enzymes utilize a variety of metabolites as co-substrates to catalyze their respective chromatin modifications, closely linking chromatin modifications and metabolism. In this study, we have investigated the role of acyl-CoA short chain synthetase family member 2 (ACSS2), the cytosolic and nuclear Acetyl-CoA synthetase of the cell, in the regulation of histone and chromatin protein post-translational modifications as well as gene expression through proteomic and genomic approaches. Support or Funding Information AJL was supported by NIH National Research Service Award T32 GM07215