Efficient evolved antibody mimetic designed ankyrin repeat proteins against programmed death-ligand 1 on E. coli surface display

Xiaoda Song,Xiaofei Chen,Li Liu,Yuting Yi,Hong Tian,Xiangdong Gao,Wenbing Yao

Biochemical Engineering Journal（2019）

引用 3|浏览12

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摘要

•E. coli surface display combined MACS are suitable for DARPins evolution.•DARPin antagonist of the immune check point protein PD-L1 was design and selected.•The evolved protein inhibited the tumor growth and have no sign of bodyweight loss.

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关键词

DARPins,Lpp,OmpA,MST,BLI,UBC

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