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SAT-190-Specific genetic elements in HBsAg C-terminus profoundly affect HBsAg levels in vivo, hamper HBsAg secretion in vitro and alter HBsAg structural stability in HBeAg-negative chronic HBV genotype D infection

Lorenzo Piermatteo,Arianna Battisti,Luca Carioti,Olympia Anastasiou,Upkar S. Gill,Luna Colagrossi,Ada Bertoli,Marianna Aragri,Alessandra Iuvara,Vincenzo Malagnino,Carlotta Cerva,Miriam Lichtner,Claudio M. Mastroianni,Giuseppe Maria De Sanctis,Paoloni Maurizio,Massimo Marignani,Caterina Pasquazzi,Nerio Iapadre,Terenzio Mari,Giustino Parruti,Jacopo Vecchiet,Loredana Sarmati,Massimo Andreoni,Angelico Mario,Sandro Grelli,Patrick Kennedy,Jens Verheyen,Francesca Ceccherini Silberstein,Carlo Federico Perno,Valentina Svicher,Romina Salpini

JOURNAL OF HEPATOLOGY（2019）

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Key words
hbsag levels,hbsag secretion,c-terminus,hbeag-negative
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