Formal synthesis of Cladospolide C & epi-Cladospolide C using R-(+)-γ-valerolactone as a chiral synthon

The formal synthesis of Cladospolide-C and its analog is achieved by using enantiopure (R)-γ–valerolactone 10. The significant points of this synthesis are the stereoselective dihydroxylation of α, β-unsaturated ester 16 using Sharpless protocol, Wittig olefination of γ –valerolactol 6 with triphenylphosphonium iodide salt 7, one pot selective oxidation of 22 and subsequent C2-homologation with good E/Z ratio.