Interferon Alpha Has a Strong Anti-tumor Effect in Philadelphia-negative Myeloproliferative Neoplasms
Clinical Lymphoma Myeloma and Leukemia(2019)
Abstract
Currently the cytoreductive approach with hydroxyurea remains the backbone treatment in myeloproliferative neoplasms. A valid, but not common alternative is interferon alfa (IFN-a).We prospectively assessed 63 patients with Philadelphia-negative myeloproliferative neoplasms treated with either hydroxyurea or IFN-a. Our data support IFN-a as a more suitable therapeutic option owing to its more profound hematologic and molecular responses and long-term disease control.
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Key words
Essential thrombocytosis,Hydroxyurea,Interferon alpha,Myeloproliferative Neoplasms,Polycythemia vera
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