Custom-made transcriptional biosensors for metabolic engineering
Current Opinion in Biotechnology(2019)
摘要
•Successful examples of transcriptional biosensor implementations are presented.•Various engineering strategies extend the space of detectable chemicals.•Novel strategies exist to transform metabolite-responding proteins into biosensors.•Mathematical models of varying complexity can help tune biosensor properties.•Biosensors using or designed for cell-free systems are presented.
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