A promising ex vivo liver protection strategy: machine perfusion and repair

Liver transplantation is a lifesaving procedure for patients with end-stage liver diseases. With the development of surgical technique, imaging, and immunosuppressant agents, postoperative survival rate has increased steadily. However, organ shortage is still a major concern. To solve the organ shortage crisis, extended criteria donors are used which include aged donors, fatty donors, and cardiac death donors; these donors need more protection.