Strychnuxinal, A New Alkaloid from Strychnos nux-blanda Fruits

A new pyrrole alkaloid, strychnuxinal (1), along with ten known compounds (2-11) were isolated from the fruits of Strychnos nux-blanda. The structures of all the isolated compounds (1-11) were fully elucidated using spectroscopic data, as well as comparisons with the previous literature data. In addition, the absolute configuration of 1 at C-8 was determined by means of the ECD calculation. Moreover, all isolated compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity.