Abstract 194: The Effect of Obstructive Sleep Apnea on the Outcomes of Patients with Supraventricular Tachycardia

Background: The obesity epidemic has become a major public health issue with repercussion through all the spectrum of cardiovascular disease. Obesity-associated pathologies like obstructive sleep apnea (OSA) have also emerged. There have been some studies associating OSA with cardiovascular disease, but the impact on outcomes is largely unknown. Purpose: evaluate the impact of OSA after adjustment for obesity on the outcomes of patients with supraventricular tachycardia (SVT). Methods: A retrospective analysis using the 2014 Healthcare Cost and Utilization Project’s Nationwide Inpatient Sample (NIS) was performed. Patients between the ages of 18 and 65 with a primary diagnosis of SVT as well as secondary diagnosis of OSA. The primary outcome was in-hospital mortality. The secondary outcomes were length of stay, cardiogenic shock, use of mechanical ventilation, acute kidney injury requiring dialysis (AKID), cost of stay, rate of direct current cardioversion (DCCV), rate of ablation, hemorrhage requiring transfusion (HRT), cardiac arrest and heart failure (HF) exacerbation. Multivariate regression analyses after adjustment for age, race, insurance, hospital location and obesity was done. Analysis was performed using Stata 15 IC. Results: 7,690 patients with a primary diagnosis of SVT and secondary diagnosis of OSA were identified. 67% of this population were female and mean age was 65 years. Patients with OSA and SVT had decreased odds of death (OR 0.53 p<0.001) as well as decreased odds of HRT (OR 0.59 p< 0.001) and development of cardiogenic shock (OR 0.51 p=0.03). Also, a non-statically significant trend towards increased AKID (OR 1.11 p=0.71), along with decreased odds of cardiac arrest (OR 0.80 p= 0.34) and stroke (OR 0.82 p=0.72) was seen. There was also increased rate of heart failure exacerbation (OR 1.42 p<0.001) in patients with OSA hospitalized for SVT. Risk of cardiac arrest (OR 0.80 p=0.34) and stroke (OR 0.82 p=0.72) exhibit a non-statically significant decreased in odds. Length of stay was showed to be less (1.3 days p<0.001) in the OSA group cohort. Conclusion: Prior studies have showed decreased mortality in OSA patients with acute myocardial infarction. This retrospective analysis demonstrated that patients with OSA had decreased mortality when hospitalized for SVT. Nevertheless, patients had increased risk of HF exacerbation. Further studies are needed to clarify the full extent of this relationship.