Reflex seizure triggering: Learning about seizure producing systems

•The activation of epilepsy-prone functional brain systems underlie reflex seizures.•Elementary system-specific stimuli cause activation in classic reflex seizures.•In praxis-induced reflex seizures high level stimuli cause system-activation.•In sleep and arousal-induced seizures normal system-functioning triggers seizures.•The reflex mechanism might be an essential component of ictogenesis.