Asymmetric cyclizations via a sequential Michael addition/Conia-ene reaction by combining multifunctional quaternary phosphonium salt and silver catalysis

A one-pot asymmetric Michael addition/Conia-ene reaction sequence, catalyzed by combination of a dipeptide-derived multifunctional quaternary phosphonium salt and Ag2CO3 has been developed, which provides a series of synthetically important chiral methylenecyclopentane derivatives in moderate to excellent yields (up to 97%) and enantioselectivities (up to 93%).