Temperature- and pH-dependent protein conformational changes investigated by terahertz dielectric spectroscopy

Ziyi Zang,Shihan Yan,Xiaohui Han,Dongshan Wei,Hong-Liang Cui,Chunlei Du

Infrared Physics & Technology（2019）

引用 13|浏览8

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摘要

•Protein folding or unfolding in solution bring about terahertz spectrum changes.•Terahertz spectrum can indicate protein denaturation induced by pH or temperature.•Terahertz spectroscopy is a potential label-free protein drugs’ quality control tool.

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关键词

Terahertz dielectric spectroscopy,Protein formulation,Protein unfolding,Temperature,pH

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