The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
FRONTIERS IN ONCOLOGY(2019)
Abstract
Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.
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Key words
BCL-2,venetoclax,AML,ALL,MDS,intrinsic apoptosis
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