Lipidomics Profiling And Progression Of Carotid Artery Atherosclerosis In Hiv-Infected Individuals

Background: Lipid metabolism disruption and excess cardiovascular disease (CVD) risk have been associated with HIV infection, yet plasma lipidomics profile and its relationship with CVD risk has been rarely examined in HIV-infected individuals. Methods: Using liquid chromatography tandem mass spectrometry, 211 plasma lipid species from 13 classes were profiled in 737 women and men aged 35-55 years (520 HIV+, 217 HIV-) from the Women’s Interagency HIV Study and the Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained in 2004-2013. Poisson regression and network analysis were used to examine associations of baseline lipids with incident carotid plaque over 7 years (112 cases, 90 HIV+ and 22 HIV-). Results: Adjusted for demographic and behavioral factors, 120 individual species from 11 lipid classes showed significant associations with incident carotid plaque (all Pu003c0.05 FDR adjusted). The risk ratios were 1.22 to 1.44 per standard deviation increment for top signific...