Macrophage Activation by a Substituted Pyrimido[5,4-b]Indole Increases Anti-Cancer Activity
Pharmacological Research（2019）
Abstract
PBI1 can polarize undifferentiated M0 macrophages or re-program tumor-promoting M2 macrophages into the anti-tumor (M1) phenotype and enhance the phagocytosis of cancer cells.
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Key words
CD47,IL-4,CS1,CSF1R,MFEG8,VEGF,SEAP,LPS,IFN-γ
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