Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
Mutation Research/Genetic Toxicology and Environmental Mutagenesis(2019)
Abstract
•Describes mechanism of aneuploidy induction.•Discusses methods to detect aneugens.•Discusses the regulatory framework for the assessment of aneugens.•Uses AOPs to describe MOA information for tubulin binders and aurora B inhibitors.
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