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BONE MORPHOGENIC PROTEIN-1/TOLLOID-LIKE METALLOPROTEINASE UPREGULATION PROFILE IN HUMAN AND MURINE ISCHEMIC HEART FAILURE

Estibaliz Castillero,Hirokazu Akashi,Catherine Wang,Marc Najjar,Ruiping Ji,Xianghai Liao, Adriana Mills, Rawan Alhau, Kaitlyn Yong, Joanna Kiperman, Jaise John,Shunichi Homma,Veli Topkara,Koji Takeda,Yoshifumi Naka,Giovanni Ferrari,Paolo Colombo,Christian Schulze,Isaac George

Journal of the American College of Cardiology（2019）

Cited 0|Views43
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Abstract
Bone morphogenic protein-1 (BMP1), mammalian tolloid (mTLD), mammalian tolloid-like 1 (mTLL1), and 2 (mTLL2) comprise the (BMP1)/tolloid-like proteinase (BTP) family. BTPs are zinc-dependent metalloproteinases that produce mature collagen fibrils and regulate extracellular matrix assembly.
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Key words
murine ischemic heart failure,heart failure,bone,tolloid-like
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