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Synthesis and anti-inflammatory effect of morachalcone B, morachalcone C, and analogs

Bo-Syuan Jhong,Ting-Yu Lin, Chien-Hsiang Kao,Hsi-Jung Yu,Tsung-Mei Chin,Ching-Yang Liu,Yuh-Chiang Shen,Ming-Jaw Don

JOURNAL OF THE CHINESE CHEMICAL SOCIETY（2019）

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Abstract
An efficient method to synthesize morachalcones B and C (1 and 2) is described. Rap-Stoermer condensation and 1,3-prenyl rearrangement were used as two key synthetic methods. Morachalcone C was obtained by photo-oxygenation of morachalcone B. Morachalcones B and C showed moderate anti-inflammatory activity.
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anti-inflammatory activity,morachalcone B,morachalcone C,Rap-Stoermer condensation
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