03:00 PM Abstract No. 383 Multifunctional iron oxide nanoparticle-embedded PVP-HEC microparticles as a drug-eluting embolic material

To develop MRI imageable novel HEC-PVP-magnetic embolic particles intended for transcatheter arterial chemoembolization and magnetic ablation. MRI imageable novel HEC-PVP-magnetic embolic microparticles were prepared from iron oxides linked with PVP using a bridging flocculation process and HEC were incorporated (coated) onto the particles to load doxorubicin (DOX), an anticancer drug for local release and killing cancerous cells. 16 male white rabbits were used in a rabbit renal embolization model. Sustained release was accomplished with 1 mg of HEC-PVP-magnetic embolic microparticles containing 16 mcg of DOX. In the chemo-TAE group, embolization was performed after catheterization of the renal artery with microcatheters. In the control TAI group, 4 mg DOX alone was injected through the renal artery. Imaging and magnetic ablation were performed after embolization using a 1.5-T high- field MR scanner equipped with high-performance gradients and fast receiver hardware. All synthesized particles calibrated in the 40-500 microns range and were easily injectable through a microcatheter. The particles exhibited no cytotoxicity against hFOB cells (P>0.05). In vivo, the particles were capable of occluding the arteries, and imageable with MRI. In the chemo-TAE group, DOX levels in kidney tissue detected after embolization were significantly higher than that in the control group (P<0.001). Infarction and necrosis in the renal cortex were observed in the Chemo-TAE group and TAE group. The maximum temperature achieved within the rabbit kidney was 48±1°C after 20 min with radiofrequency exposures at 25 kW. HEC-PVP-Magnetic embolic microparticles can be loaded with an anticancer drug to be useful for embolization therapies with traceability and magnetic ablation properties.