High Information Content Assays for Genetic Toxicology Testing: A Report of the International Workshops on Genotoxicity Testing (IWGT)

Stephen D. Dertinger,Yukari Totsuka,Jason H. Bielas,Ann T. Doherty,Jos Kleinjans,Masamitsu Honma,Francesco Marchetti,Maik J. Schuler,Veronique Thybaud,Paul White,Carole L. Yauk

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

引用 7|浏览38

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摘要

•The IWGT evaluated high information content data streams for genotoxicity testing.•Strengths, weaknesses, opportunities, and threats were considered.•Strengths include high throughput and provision of mechanistic insight.•Immediate uses include screening, prioritization and integrated testing.

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关键词

Genetic toxicology,Adductomics,Transcriptomics,Error-reduced sequencing,High information content,New technologies

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