Palladium‐Catalyzed C−H Arylation of Aliphatic and Aromatic Ketones using Dipeptide Transient Directing Groups
ASIAN JOURNAL OF ORGANIC CHEMISTRY(2019)
摘要
Ketones are ubiquitous structural motifs in chemical materials and medicinally active pharmaceutical ingredients. Transition metal-catalyzed C-H bond functionalization is one of the most efficient tactics for diversification of ketones. Palladium-catalyzed C-H arylation of aliphatic and aromatic ketones has been achieved utilizing an inexpensive dipeptide as a transient directing group. The tridentate coordination used in this reaction enhances the reactivity of the substrates and allows reduction of the loading of the directing group compounds to 20%. This approach allows rapid arylation of complex natural products, medicinal-chemistry-related scaffolds, and even remote C(sp(2))-H bonds.
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关键词
ketones,C-H activation,peptides,tridentate coordination,arylation
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