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Indirect Electrochemical Determination of Ribavirin Using Boronic Acid-Diol Recognition on a 3-Aminophenylboronic Acid-Electrochemically Reduced Graphene Oxide Modified Glassy Carbon Electrode (APBA/ERGO/GCE)

ANALYTICAL LETTERS(2019)

Cited 7|Views31
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Abstract
A novel method for the indirect electrochemical determination of ribavirin based on boronic acid-diol recognition was developed using the platform as the sensing element. The device was constructed using a 3-aminophenylboronic acid (APBA)-electrochemically reduced graphene oxide (ERGO) modified electrode. When the electrode was immersed in a solution of ribavirin, complexation of boronic acid groups of APBA with ribavirin occurred at the surface of the electrode and simultaneously caused steric hindrance, resulting in a current decrease because the ferricyanide redox probe was unable access the surface. Under the optimized conditions, a linear relationship was obtained between the relative change in current (%Delta i) of [Fe(CN)(6)](3-/4-)and the concentration of ribavirin at levels from 10.0 to 7.50 x 10(2) ng mL(-1). The proposed electrochemical sensor performed with acceptable sensitivity and reproducibility and was successfully used to determine the content of ribavirin in an injection with satisfactory results.
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Key words
3-aminophenylboronic acid,3-aminophenylbornic acid-electrochemically reduced graphene oxide modified glassy carbon electrode (APBA,ERGO,GCE),electrochemical sensor,graphene oxide,ribavirin
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