Effects of silkworm pupa protein hydrolysates on mitochondrial substructure and metabolism in gastric cancer cells

The effects of silkworm pupa protein hydrolysates (SPPHs) on the apoptosis of MGC-803 gastric cancer cells were investigated in this study. The role of mitochondrial-dependent apoptosis in SPPHs-dependent inhibition of MGC-803 cell viability was also explored. SPPHs were found to induce apoptosis in MGC-803 cells with an IC50 of 0.30 mg/ml.