Whole-genome informed circulating tumor DNA analysis by multiplex digital PCR for disease monitoring in B-cell lymphomas: a proof-of-concept study.
Frontiers in oncology(2023)
摘要
In summary, we demonstrate that multi-targeted cfDNA analysis, using a combination of SNVs/indels and SVs candidates identified by WGS analysis, provides a sensitive tool for MRD monitoring and can detect lymphoma relapse earlier than clinical manifestation.
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关键词
cell-free DNA (cfDNA), whole genome sequence (WGS), liquid biopsy, lymphoma, measurable (minimal) residual disease (MRD), droplet digital (ddPCR), CtDNA, IGH-BCL2 translocation
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