Intracortical inhibition of the parietal cortex is associated with cognitive function in older adults: A TMS-EEG study

Shifts in cortical excitation/inhibition (E/I) balance are likely contributors to age-related decline in cognitive functions. The inferior parietal lobule (IPL) and the dorsolateral prefrontal cortex (DLPFC) are key hubs in the fronto-parietal networks engaged in attentional and fluid intelligence processes. As part of the Barcelona Brain Health Initiative (https://bbhi.cat), the purpose of this study is to investigate the associations between cortical E/I balance in these regions with cognitive function in cognitively intact, middle to older age-adults.